The Census Bureau’s definition consists of 12 states in the north central United States: Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, and Wisconsin. The region generally lies on the broad Interior Plain between the states occupying the Appalachian Mountain range and the states occupying the Rocky Mountain range. Major rivers in the region include, from east to west, the Ohio River, the Upper Mississippi River, and the Missouri River. A 2012 report from the United States Census put the population of the Midwest at 65,377,684. The Midwest is divided by the Census Bureau into two divisions. The East North Central Division includes Illinois, Indiana, Michigan, Ohio, and Wisconsin, all of which are also part of the Great Lakes region. The West North Central Division includes Iowa, Kansas, Minnesota, Missouri, North Dakota, Nebraska, and South Dakota, several of which are located, at least partly, within the Great Plains region.
Chicago is the most populous city in the American Midwest and the third most populous in the entire country. Other large Midwestern cities include (in order by population): Columbus, Indianapolis, Detroit, Milwaukee, Kansas City, Omaha, Minneapolis, Wichita, Cleveland, St. Paul, St. Louis, and Cincinnati. Chicago and its suburbs, called Chicagoland, form the largest metropolitan area with 10 million people. Other large metropolitan areas include Metro Detroit, Minneapolis–St. Paul, Greater St. Louis, Greater Cincinnati, the Kansas City metro area, the Columbus metro area, and Greater Cleveland.